Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Blaine N. Armbruster, Xiang Li, Mark H. Pausch, +2

Proceedings of the National Academy of Sciences

Family MembersMolecular BiologyInert LigandCell SignalingMolecular Physiology +14

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Michael J. Krashes, Shuichi Koda, Chian-Ping Ye, +6

Journal of Clinical Investigation

Food IntakeGastrointestinal Peptide HormoneNeural MechanismHypothalamic PeptideAppetite Control +16

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

D. Gowanlock R. Tervo, Bum-Yeol Hwang, Sarada Viswanathan, +14

Neuron

Projection NeuronsEngineeringNeuroengineeringComputational NeuroscienceNeural Recoding +6

Amygdala circuitry mediating reversible and bidirectional control of anxiety

Kay M. Tye, Rohit Prakash, Sung‐Yon Kim, +7

Nature

Experimental PsychopathologyPsychiatryNeurobiological FactorAffective NeurosciencePsychopharmacology +7

Transgenic Mice for Intersectional Targeting of Neural Sensors and Effectors with High Specificity and Performance

Linda Madisen, Aleena R. Garner, Daisuke Shimaoka, +23

Neuron

Knockout MouseMolecular NeuroscienceTransgenic Mouse ModelsMedicineHigh Specificity +7

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

Juan L. Gomez, Jordi Bonaventura, Wojciech G. Lesniak, +10

Science

PsychopharmacologyPharmacotherapySocial SciencesMolecular PharmacologyDrug Design +16

Switching on and off fear by distinct neuronal circuits

Cyril Herry, Stéphane Ciocchi, Verena Senn, +3

Nature

Neurobiological MechanismCognitive ScienceBrain MechanismNeural CircuitsAffective Neuroscience +5

Encoding of conditioned fear in central amygdala inhibitory circuits

Stéphane Ciocchi, Cyril Herry, François Grenier, +9

Nature

Neurobiological MechanismNeuropsychologyPsychiatryNeurobiological FactorInhibitory Process +5

Genetic dissection of an amygdala microcircuit that gates conditioned fear

Wulf Haubensak, Prabhat S. Kunwar, Haijiang Cai, +10

Nature

Neurobiological MechanismPsychiatryBrain MechanismNeuroanatomyGenetic Dissection +5

Midbrain circuits for defensive behaviour

Philip Tovote, Maria Soledad Esposito, Paolo Botta, +10

Nature

Behavioral SciencesNeural MechanismBehavioral NeuroscienceNeural CircuitsMidbrain Circuits +7