False-Positive Results for Human Immunodeficiency Virus Type 1 Nucleic Acid Amplification Testing in Chimeric Antigen Receptor T Cell Therapy

Jocelyn R. Hauser, Hong Hong, N. Esther Babady, Genovefa A. Papanicolaou, Yi‐Wei Tang

Journal of Clinical Microbiology · 2019 · 16 citations · 2 references

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Abstract

and the long terminal repeat [LTR]). These samples subsequently retested negative using the Abbott m2000 RealTime HIV-1 assay, which targets the integrase gene. These results indicated that cross-reactions between lentiviral vectors and LTR genomes targeted in the HIV-1 NAAT caused the HIV-1 NAAT false-positive results.

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