Concepedia

GSTM1 Deletion Exaggerates Kidney Injury in Experimental Mouse Models and Confers the Protective Effect of Cruciferous Vegetables in Mice and Humans

Joseph C. Gigliotti, Adrienne Tin, Shirin Pourafshar, Sylvia Cechova, Yves T. Wang, Sun‐Sang J. Sung, Gabor Bodonyi-Kovacs, Janet V. Cross, Guang Yang, Nhu Nguyen,

Journal of the American Society of Nephrology · 2019 · 43 citations · 44 references

DOIFull text

Open access

Abstract

Our data support a role for the GSTM1 enzyme in the modulation of oxidative stress, inflammation, and protective metabolites in CKD.

References

44

Metabolic gene polymorphism frequencies in control populations.

Seymour Garte, Laura Gaspari, Anna-Karin Alexandrie et al. · PubMed · 2001 · 847 citations

, , +17

Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China

Stephanie J. London, Jian‐Min Yuan, Fung‐Lung Chung et al. · The Lancet · 2000 · 438 citations

, , +13

Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidationby human glutathione transferases.

Kiflu Berhane, Mikael Widersten, Åke Engström et al. · Proceedings of the National Academy of Sciences · 1994 · 410 citations · Full text

, , +17

Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1

Ssang‐Goo Cho, Yong Hee Lee, Hee-Sae Park et al. · Journal of Biological Chemistry · 2001 · 399 citations · Full text

, , +20

Human glutathione transferase A4-4: an Alpha class enzyme with high catalytic efficiency in the conjugation of 4-hydroxynonenal and other genotoxic products of lipid peroxidation

Ina Hubatsch, Marianne Ridderström, Bengt Mannervik · Biochemical Journal · 1998 · 374 citations · Full text