Analytical Quality by Design Approach for a Stability-Indicating Method to Determine Apixaban and Its Related Impurities

The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement

Michael R. Lassen, Bruce L. Davidson, Alexander Gallus et al. · Journal of Thrombosis and Haemostasis · 2007 · 370 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +14

Apixaban, an oral, direct factor <scp>X</scp>a inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects

Charles Frost, Jessie J. Wang, Sunil Nepal et al. · British Journal of Clinical Pharmacology · 2012 · 363 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +13

Application of quality by design to the development of analytical separation methods

Serena Orlandini, S. Pinzauti, Sandra Furlanetto · Analytical and Bioanalytical Chemistry · 2012 · 235 citations

Pharmacy, Chemical Engineering, Chemistry +9

‘Quality by Design’ approach for the analysis of impurities in pharmaceutical drug products and drug substances

Amandine Dispas, H. Avohou, Pierre Lebrun et al. · TrAC Trends in Analytical Chemistry · 2017 · 118 citations

Pharmacy, Pharmaceutical Analysis, Pharmaceutics +17

Design Space of Pharmaceutical Processes Using Data-Driven-Based Methods

Fani Boukouvala, Fernando J. Muzzio, Marianthi Ierapetritou · Journal of Pharmaceutical Innovation · 2010 · 89 citations

Pharmacy, Pharmaceutics, Data-driven Design +13