Mutation profile and its correlation with clinicopathology in Chinese hepatocellular carcinoma patients

Abstract

The most frequently mutated genes of HCC patients in China were <i>TP53</i>, <i>TERT</i>, and <i>CTNNB1</i>, which mainly lead to the occurrence and development of HCC by regulating the P53 pathway, Wnt pathway, and telomere repair pathway. There were more patients with microvascular invasion and Edmondson III-IV grade in <i>TP53</i> mutated patients and more patients with hepatic capsule invasion in <i>TERT</i> mutated patients, while in <i>CTNNB1</i> mutated patients, there were more patients with Edmondson I-II grade, AFP <25 µmg/L, and a non-hepatitis B background. Also, the TMB values were significantly higher in <i>CTNNB1</i> mutated patients than in wild type patients.