Concepedia

The Benefit of Dexmedetomidine on Postoperative Cognitive Function Is Unrelated to the Modulation on Peripheral Inflammation

Bin Mei, Guanghong Xu, Wei Han, Xiao‐Long Lu, Ruihong Liu, Xinqi Cheng, Shishou Chen, Erwei Gu, Xuesheng Liu, Ye Zhang

Clinical Journal of Pain · 2019 · 32 citations · 27 references

DOI

Abstract

Intraoperative sedation with dexmedetomidine conferred better postoperative neurocognitive function for elderly patients who received total knee arthroplasty. This effect was unrelated to the modulation of dexmedetomidine on peripheral inflammation.

References

27

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Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial

Xian Su, Zhaoting Meng, Xinhai Wu et al. · The Lancet · 2016 · 773 citations · Full text

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Postoperative Delirium in Older Adults: Best Practice Statement from the American Geriatrics Society

Sharon K. Inouye, Thomas N. Robinson, Caroline Blaum et al. · Journal of the American College of Surgeons · 2014 · 483 citations

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