Links Between Physical Frailty and Regional Gray Matter Volumes in Older Adults: A Voxel-Based Morphometry Study

Abstract

The weakness and slowness components of physical frailty were linked to reduced gray matter volume in brain regions associated with not only physical mobility but also cognitive functions and social processes. This study addressed the underlying mechanisms in the progression of physical, cognitive, and social frailty, from the perspective of brain structures that are associated with frailty.