Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer

Xuan Deng, Sihan Li, Fanyang Kong, Haoyu Ruan, Xiao Xu, Xinju Zhang, Zhiyuan Wu, Lin Zhang, Ying Xu, Hong Yuan,

Theranostics · 2019 · 60 citations · 3 references

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Abstract

Our study illustrates how cancer cells hijack the PiHL-p53 axis to promote CRC progression and chemoresistance. PiHL plays an oncogenic role in CRC carcinogenesis and is an independent prognostic factor as well as a potential therapeutic target for CRC patients.

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