Concepedia

Extracellular vesicle-mediated delivery of miR-101 inhibits lung metastasis in osteosarcoma

Kailiang Zhang, Chuan Dong, Ming Chen, Tong-Tao Yang, Xin Wang, Yongheng Gao, Lijuan Wang, Yanhua Wen, Guanyin Chen, Xiuchun Yu,

Theranostics · 2019 · 175 citations · 36 references

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Abstract

Our data support the function of miR-101 as a tumor suppressor in osteosarcoma via downregulation of BCL6. AD-MSC derived miR-101-enriched EVs represent a potential innovative therapy for metastatic osteosarcoma. EV-miR-101 also represents a promising circulating biomarker of osteosarcoma metastasis.

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36

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