Cancer Cell Membrane‐Camouflaged Micromotor

Abstract

Abstract A type of cancer cell membrane‐camouflaged and gold nanoshell‐functionalized CaCO 3 (CGNCaCO 3 ) micromotor and its ability to modulate immune activity are described. The process used to fabricate these micromotors includes the synthesis of CaCO 3 particles, the functionalization of the gold nanoshell, and the fusion of cancer cell membrane vesicles onto the gold nanoshell‐functionalized CaCO 3 (GNCaCO 3 ) particles. Due to the benefit of the homotypic binding of the cancer cell membrane, the autonomous movement of CGNCaCO 3 micromotors results in their substantial accumulation on cancer cells. The subcutaneous injection of CGNCaCO 3 micromotors enhances their immune activity by camouflaging cancer cells. Such CGNCaCO 3 micromotors inherit the biological features of natural cancer cells and are able to facilitate a broad range of antigenic and biological processes that common synthetic motors cannot achieve, and thus, these micromotors hold considerable promise for a number of practical biomedical uses.