Concepedia

Small molecule TSC01682 inhibits osteosarcoma cell growth by specifically disrupting the CUL4B-DDB1 interaction and decreasing the ubiquitination of CRL4B E3 ligase substrates.

Bin Chen, Yu Feng, Meimei Zhang, Guangqi Cheng, Hantao Wang

PubMed · 2019 · 11 citations · 18 references

Concepts

Abstract

tumor growth. Collectively, our results suggest that TSC01682 is a potent compound capable of disrupting the CUL4B-DDB1 interaction, and it may be developed as a chemotherapeutic drug for osteosarcoma treatment.

References

18

A Family of Diverse Cul4-Ddb1-Interacting Proteins Includes Cdt2, which Is Required for S Phase Destruction of the Replication Factor Cdt1

Jianping Jin, Emily E. Arias, Jing Chen et al. · Molecular Cell · 2006 · 640 citations · Full text

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Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage

Hengbin Wang, Ling Zhai, Jun Xu et al. · Molecular Cell · 2006 · 503 citations · Full text

, , +15

The Roles of Post-translational Modifications in the Context of Protein Interaction Networks

Guangyou Duan, Dirk Walther · PLoS Computational Biology · 2015 · 433 citations · Full text

, , +17

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation

Hideo Nishitani, Yasushi Shiomi, Hiroka Iida et al. · Journal of Biological Chemistry · 2008 · 241 citations · Full text

, , +17

Cullin 4A Associates with the UV-damaged DNA-binding Protein DDB

Pavel Shiyanov, Alo Nag, Pradip Raychaudhuri · Journal of Biological Chemistry · 1999 · 157 citations · Full text

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