Silicon dioxide nanoparticles induce insulin resistance through endoplasmic reticulum stress and generation of reactive oxygen species

Abstract

Silicon dioxide NPs induced IR through ER stress and generation of ROS, but SiO₂ FPs did not. Therefore, lifelong exposure of humans to SiO₂ NPs may result in detrimental effects on blood glucose. The results of this study strongly suggested that non-nanoformed SiO₂ should be used as food additives.