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E-pharmacophore guided discovery of pyrazolo[1,5-c]quinazolines as dual inhibitors of topoisomerase-I and histone deacetylase

BiochemistryDual InhibitorsMedicineRational Drug DesignPharmacotherapyAnti-cancer AgentDrug DevelopmentPharmacologyHistone DeacetylaseInhibitory ActivityDrug DiscoveryGuided Discovery