Distinguishing naive‐ from memory‐derived human B cells during acute responses

Abstract

Stimulation with R848, IL-21 and sCD40L in the presence of monocytes induces robust differentiation and ASC generation from both naive and memory B-cells. However, naive and memory B cells retain key phenotypic differences after activation that may facilitate <i>ex vivo</i> discrimination and better characterisation of acute responses to variant antigens.