Lower facial regeneration with a combination of platelet‐rich fibrin liquid matrices based on the low speed centrifugation concept‐Cleopatra technique

Abstract

BACKGROUND: Autologous blood concentrates are increasingly being applied in esthetic medicine and dentistry due to their safety and their potential beneficial properties. Platelet-rich fibrin based on the low speed centrifugation, a newly described blood product, seems to convey additional properties in several in vitro and ex vivo studies. Its clinical significance however in relation to facial regeneration remains anecdotal. OBJECTIVE: The aim of this study was to assess a specific combination of PRF liquid matrices utilized for lower facial regeneration (Cleopatra technique). PATIENTS/METHODS: Cleopatra technique was applied in 32 patients. In addition to recording of all patients' complaints and adverse events, a photographical study was performed. Possible positive effects were assessed by asking twenty-three independent reviewers to distinguish initial and later photographs of each patient. RESULTS: A statistically significant percentage of true answers by the reviewers was noted upon completion of the treatment (U = 110.5, P < .001), which indicates a clinically significant effect of Cleopatra technique. Moreover, only few minor, self-limited adverse events were recorded. CONCLUSIONS: Cleopatra technique is a well-tolerated and effective method of lower facial rejuvenation that deserves further attention from dentists and other health professional who utilize conservative methods in facial esthetics.