First Detection of NDM-5-Positive <i>Salmonella enterica</i> Serovar Typhimurium Isolated from Retail Pork in China

Abstract

In this study, a carbapenem-resistant <i>Salmonella enterica</i> serovar Typhimurium strain W131 (sequence type 34) was isolated from retail pork in Jiangsu province, China. An IncX3 plasmid carrying <i>bla</i>_NDM-5 element was identified in this strain by whole-genome sequencing analysis. The conjugation experiment demonstrated that the plasmid can be transferred to <i>Escherichia coli</i> recipient J53 and conferred carbapenem resistance to the recipient strain. This study first reported a <i>Salmonella</i> Typhimurium strain with <i>bla</i>_NDM-5 from retail pork, which revealed that retail meat as a potential transmission factor of carbapenem-resistant <i>bla</i>_NDM-5 to be a threat human health.