Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis‐associated cachexia

Abstract

We report the novel findings that correction of 25(OH)D₃ and 1,25(OH)₂ D₃ insufficiency reverses cachexia and may improve quality of life by restoring muscle function in an animal model of infantile nephropathic cystinosis. Mechanistically, vitamin D repletion attenuates adipose tissue browning and muscle wasting in Ctns^-/- mice via multiple cellular and molecular mechanisms.