The Effects Of Particulate Cobalt, Chromium And Cobalt-chromium Alloy On Human Osteoblast-like Cells In Vitro

Abstract

Particulate wear debris can induce the release of bone-resorbing cytokines from cultured macrophages and fibroblasts in vitro, and these mediators are believed to be the cause of the periprosthetic bone resorption which leads to aseptic loosening in vivo. Much less is known about the effects of particulate debris on the growth and metabolism of osteoblastic cells.