Alzheimer's Prevention Initiative Generation Program: Development of an <i>APOE</i> genetic counseling and disclosure process in the context of clinical trials

Abstract

The API Genetic Counseling and Disclosure Process provides a framework for large-scale disclosure of <i>APOE</i> genotype results to study participants and serves as a model for disclosure of biomarker results. The process provides education to participants about the meaning and implication(s) of their <i>APOE</i> results while also incorporating a comprehensive assessment of disclosure impact. Data assessing participant safety and psychological well-being before and after <i>APOE</i> disclosure are still being collected and will be presented in a future publication.