Vasodilation of rat skeletal muscle arteries by the novel BK channel opener GoSlo is mediated by the simultaneous activation of BK and K_v7 channels

Abstract

This study shows that GoSlo-SR compounds are effective relaxants in vascular smooth muscle and mediate their effects by a combined activation of BK and K_v 7.4/K_v 7.5 channels. Activation of K_v 1, K_v 2 or K_v 7.1 channels or other vasodilator pathways seems not to be involved.