Population pharmacokinetics of vancomycin in obesity: Finding the optimal dose for (morbidly) obese individuals

Abstract

In this prospective, rich sampling pharmacokinetic study, vancomycin clearance was well predicted using TBW. We recommend that in obese individuals without renal impairment, vancomycin should be dosed as 35 mg kg^-1 day^-1 (maximized at 5500 mg/day). When given over 2 daily doses, trough concentrations of 5.7-14.6 mg L^-1 correspond to the target exposure in obese individuals.