Nucleophilic (Phenylsulfonyl/arylthio)difluoromethylation of Aldehydes with TMSCF₂Br: A Three-Component Strategy

Abstract

An efficient method for nucleophilic (phenylsulfonyl/arylthio)difluoromethylation of aldehydes with TMSCF₂Br was developed. The reaction proceeds through in situ generation of difluorocarbene, which is captured by PhSO₂Na or ArSNa to form the corresponding PhSO₂CF₂^- or PhSCF₂^- anions, followed by nucleophilic addition to aldehydes to give the desired difluoromethylated products.