Synaptic Proteome Alterations in the Primary Auditory Cortex of Individuals With Schizophrenia

Abstract

These findings suggest a robust and highly coordinated rearrangement of the synaptic proteome. In line with unbiased genetic findings, alterations in synaptic levels of postsynaptic proteins were identified, providing a road map to identify the specific cells and circuits that are impaired in individuals with schizophrenia A1.