Tranexamic Acid for Melasma: Evaluating the Various Formulations.

Abstract

Melasma is a common dermatological condition that can be notoriously difficult to treat. Topical bleaching agents and strict photoprotection, in addition to adjuvant treatment modalities, such as chemical peels and laser treatments, have been shown to provide only minimal improvements in the condition. Recently, tranexamic acid has shown promise. Topical, intradermal, and oral formulations of tranexamic acid have been studied, with oral formulations demonstrating the greatest, albeit temporary, improvement. In this brief review, we discuss the different formulations of tranexamic acid for melasma and offer suggestions for future directions of research.