<p>Overexpression of SOX9 alleviates the progression of human osteoarthritis in vitro and in vivo</p>

Abstract

Upregulation of SOX9 inhibited IL-1β-induced inflammatory response via increasing the level Smad3 in human chondrocytes and exhibited therapeutic effect on surgically induced OA mice in vivo. Therefore, SOX9 may serve as a potential target in the treatment of OA in the future.