Hypersynchronization in mild cognitive impairment: the ‘X’ model

Abstract

Hypersynchronization has been considered as a biomarker of synaptic dysfunction along the Alzheimeŕs disease continuum. In a longitudinal MEG study, Pusil et al. reveal changes in functional connectivity upon progression from MCI to Alzheimer’s disease. They propose the ‘X’ model to explain their findings, and suggest that hypersynchronization predicts conversion.