Diisobutylaluminum-Promoted Regioselective De-O-benzylation of Perbenzylated Cyclodextrins: A Powerful New Strategy for the Preparation of Selectively Modified Cyclodextrins

Abstract

A new solution to an old problem: Remarkably regioselective de-O-benzylation of perbenzylated cyclodextrins (CDs) such as 1 (or α- and γ-CDs) occurs with diisobutylaluminum hydride, thus providing an innovative approach to the preparation of selectively modified cyclodextrins such as 2 in excellent yield.