Neuroprotective potential of new chromones isolated from the soil actinomycete <i>Microbispora</i> sp. TBRC6027

Abstract

Nine new chromone analogs (<b>1</b>-<b>9</b>) were isolated from the soil actinomycete <i>Microbispora</i> sp. TBRC6027. The chemical structures were determined based upon NMR spectroscopic methods. These compounds were evaluated <i>in vitro</i> by using P19-derived neurons for neuroprotective activity against oxidative stress induced by serum deprivation and showed % viability of neurons at the concentration of 1 ng/mL varied from 43.51% to 52.99% without significant neurotoxicity for P19-derived neurons at the same concentration. Moreover, all tested compounds were inactive for antibacterial activity against both Gram-positive and Gram-negative bacteria and for cytotoxicity against MCF-7 (human breast cancer) and Vero cells at maximum tested concentration 50 μg/mL. However, compounds <b>4</b>, <b>6</b>, and <b>7</b> displayed weak cytotoxicity against NCI-H187 (human small-cell lung cancer) cells with IC₅₀ in a range of 87.99-91.57 μM.