Concepedia

A common variant in <i>CCDC93</i> protects against myocardial infarction and cardiovascular mortality by regulating endosomal trafficking of low-density lipoprotein receptor

Antoine Rimbert, Nawar Dalila, Justina C. Wolters, Nicolette Huijkman, Marieke Smit, Niels Kloosterhuis, Marijn Riemsma, Ydwine van der Veen, Amika Singla, Freerk van Dijk,

European Heart Journal · 2019 · 26 citations · 34 references

DOIFull text

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Abstract

This study provides evidence that a common variant in CCDC93, encoding a protein involved in recycling of the LDLR, is associated with lower LDL-c levels, lower risk of MI and cardiovascular mortality.

References

34

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Sequence Variations in <i>PCSK9,</i> Low LDL, and Protection against Coronary Heart Disease

Jonathan C. Cohen, Eric Boerwinkle, Thomas H. Mosley et al. · New England Journal of Medicine · 2006 · 3.1K citations · Full text