Publication | Closed Access
Why does tautomycetin thioesterase prefer hydrolysis to macrocyclization? Theoretical study on its catalytic mechanism
13
Citations
40
References
2019
Year
Theoretical StudyBiochemistryTautomycetin ThioesteraseNatural SciencesBiocatalysisTe-catalyzed HydrolysisTmc TeEnzyme CatalysisSynthetic BiologyMolecular BiologyStructure-function Enzyme KineticsPrefer HydrolysisChemical BiologyCatalytic MechanismEnzymatic Modification
In this study, we attempted to uncover the reasons why Tautomycetin thioesterase (TMC TE) prefers hydrolysis rather than macrocyclization, and reveal the molecular basis of TE-catalyzed hydrolysis and macrocyclization.
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