Impaired Autophagy in CD11b ⁺ Dendritic Cells Expands CD4 ⁺ Regulatory T Cells and Limits Atherosclerosis in Mice

Abstract

In contrast to its proatherogenic role in macrophages, autophagy disruption in DCs induces a counter-regulatory response that maintains immune homeostasis in <i>Ldlr</i>^-/- mice under high-fat diet and limits atherogenesis. Selective modulation of autophagy in DCs could constitute an interesting therapeutic target in atherosclerosis.