Annals of General Psychiatry · 2019 · 15 citations · 11 references
MedicinePharmacotherapyPsychiatryChild PsychiatryPediatric PharmacotherapyPsychopharmacologyPediatric Clinical TrialsPediatric PsychopharmacologyPsychopharmacology In AdolescentsPsychopharmacology In ChildrenTic DisordersTourette SyndromeAripiprazole PharmacologyGilles De La Tourette SyndromeMotor Tic ReductionPediatric TicsPediatric Tourette Syndrome TreatmentPharmacotherapy For TicsTic Severity AssessmentYale Global Tic Severity Scale
OBJECTIVE: This study compared the efficacy and tolerability of sodium valproate and aripiprazole in the treatment of Tourette syndrome (TS). METHOD: 24 children and adolescents with a diagnosis of TS from the Jiamusi Central Hospital between January 2014 and August 2017 were randomly divided into sodium valproate group and aripiprazole group according to the order of clinic visits and treated for 10 days. Tic severity was rated using the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impressions Scale for tics (CGI-Tics) and the adverse reactions were valued using the Treatment Emergent Symptom Scale (TESS) at baseline and at each follow-up visit. RESULTS: < 0.05) than the sodium valproate group. There was no significant difference in TESS score between the two groups. CONCLUSIONS: The study indicates that the patients treated with sodium valproate injection have a faster onset time than the patients treated with oral aripiprazole in controlling tics.
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Rating scales and checklists for child psychopharmacology.
C. Keith Conners, Russell A. Barkley · PubMed · 1985 · 185 citations