Effect of Curcumin and Nano-curcumin on Reduce Aluminum Toxicity in Rats

Abstract

Aluminum is a ubiquitous toxic metal that mainly affects brain, bone, spleen, liver, kidney, hepatic hematopoietic system. This study investigated the effect of Curcumin and Curcumin Nanoparticles on reduced the toxicity of aluminum chloride in treated rats. Six groups of rats were used: (1) control; (2) curcumin-treated rats (15 mg curcumin /Kg BW; (3) Nano-curcumin -treated rats (15 mg Nano-curcumin /Kg BW); (4) aluminum chloride-treated rats (100 mg/kg BW); (5) AlCl₃- curcumin-treated rats (100 mg AlCl₃ and 15 mg curcumin/kg BW); (6) AlCl₃- Nano-curcumin -treated rats (100 mg AlCl₃ and 15 mg Nano-curcumin /kg BW). The treatment with AlCl₃ alone caused significant (P≤ 0.05) increased in liver and kidney functions of rats, while the oral intake of curcumin and Nano-curcumin eliminate the harmful effect of AlCl₃. On the same side, the treatment with AlCl₃ alone significantly (P≤ 0.05) increase the free radical level and decreased the activities of antioxidant enzymes in plasma, while the treatment with curcumin and Nano-curcumin reduced this increased in free radicals and increased the activities of antioxidant enzymes. These results confirmed that the curcumin and Nano-curcumin reduced the toxicity effect of AlCl₃ in rats; moreover, Nano-curcumin has a best biological and antioxidant activity than curcumin in healthy and AlCl₃-treated rats.