Au‐Catalyzed Stereoselective Ritter Reaction of Haloalkynes with Nitriles for (<i>Z</i>)‐<i>β</i>‐Halogenated Enamides

Abstract

An efficient and stereoselective protocol has been developed for the synthesis of ( Z )‐ β ‐halogenated enamide through gold catalyzed Ritter reaction. In the presence of 2 mol% BrettPhosAuCl and 2 mol% AgNTf 2 , a broad range of nitriles smoothly underwent Ritter reaction with aromatic, vinylic or aliphatic haloalkynes to give structurally diverse ( Z )‐ β ‐halogenated enamides in excellent to good yields.