Concepedia

Metformin Effects on FOXP3<sup>+</sup> and CD8<sup>+</sup> T Cell Infiltrates of Head and Neck Squamous Cell Carcinoma

Dev Amin, Tony Richa, Mehri Mollaee, Tingting Zhan, Patrick Tassone, Jennifer M. Johnson, Adam Luginbuhl, David M. Cognetti, Ubaldo Martinez‐Outschoorn, Robert Stapp,

The Laryngoscope · 2019 · 38 citations · 34 references

DOI

Abstract

1b. This study is most accurately described as a non-randomized controlled trial and therefore may reflect a level of evidence below 1b but above 2a from the provided "levels of evidence" chart. Laryngoscope, 130:E490-E498, 2020.

References

34

Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

Shohei Hori, Takashi Nomura, Shimon Sakaguchi · Science · 2003 · 8K citations

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Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck

James A. Bonner, Paul M. Harari, J. Giralt et al. · New England Journal of Medicine · 2006 · 5.1K citations · Full text

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

Robert L. Ferris, George R. Blumenschein, Jérôme Fayette et al. · New England Journal of Medicine · 2016 · 4.9K citations · Full text

Intraepithelial CD8<sup>+</sup>tumor-infiltrating lymphocytes and a high CD8<sup>+</sup>/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Eiichi Sato, Sara H. Olson, Jiyoung Ahn et al. · Proceedings of the National Academy of Sciences · 2005 · 2.4K citations · Full text

Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial

Tanguy Y. Seiwert, Barbara Burtness, Ranee Mehra et al. · The Lancet Oncology · 2016 · 1.7K citations

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