Concepedia

TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates

Rajesh Kumar Singh, Abigail S. Haka, Arky Asmal, Valéria C. Barbosa-Lorenzi, Inna Grosheva, Harvey F. Chin, Yuquan Xiong, Timothy Hla, Frederick R. Maxfield

Arteriosclerosis Thrombosis and Vascular Biology · 2019 · 67 citations · 54 references

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Abstract

We present a mechanism in which interaction of macrophages with agLDL initiates a TLR4 signaling pathway, resulting in formation of the lysosomal synapse, catabolism of agLDL, and lipid accumulation in vitro and in vivo.

References

54

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