Controlling silk fibroin conformation for dynamic, responsive, multifunctional, micropatterned surfaces

Abstract

Protein micro/nanopatterning has long provided sophisticated strategies for a wide range of applications including biointerfaces, tissue engineering, optics/photonics, and bioelectronics. We present here the use of regenerated silk fibroin to explore wrinkle formation by exploiting the structure-function relation of silk. This yields a biopolymer-based reversible, multiresponsive, dynamic wrinkling system based on the protein's responsiveness to external stimuli that allows on-demand tuning of surface morphologies and properties. The polymorphic transitions of silk fibroin enable modulation of the wrinkle patterns and, consequently, the material's physical properties. The interplay between silk protein chains and external stimuli enables control over the protein film's wrinkling dynamics. Thanks to the versatility of regenerated silk fibroin as a technological substrate, a number of demonstrator devices of varying utility are shown ranging from information encoding to modulation of optical transparency and thermal regulation.