<scp>l</scp>-Serine Lowers the Inflammatory Responses during Pasteurella multocida Infection

Abstract

<i>Pasteurella multocida</i> causes a variety of infectious diseases in various species of mammals and birds, resulting in enormous economic loss to the modern livestock and poultry industry. However, the mechanism of host-pathogen interaction is unclear. Here, we found that l-serine levels were significantly decreased in murine lungs infected with <i>P. multocida</i> Exogenous l-serine supplementation significantly increased the survival rate of mice and decreased the colonization of <i>P. multocida</i> in the lungs of mice. Notably, l-serine decreased the macrophage- and neutrophil-mediated inflammatory responses in mice during <i>P. multocida</i> infection.