A new labdane-type diterpenoid from the leaves of <i>Vitex negundo</i> L.

Abstract

A new labdane-type diterpenoid, named vitexnegundin (<b>1</b>), along with seven known compounds, including vitexilactone (<b>2</b>), vitetrifolin D (<b>3</b>), 13-hydroxy-5(10),14-halimadien-6-one (<b>4</b>), (rel 3<i>S</i>,5<i>S</i>,8<i>R</i>,9<i>R</i>,10<i>S</i>)-3,9-dihydroxy-13(14)-labden-16,15-olide (<b>5</b>), artemetin (<b>6</b>), vitexcarpin (<b>7</b>) and penduletin (<b>8</b>), were isolated from the leaves of <i>Vitex negundo</i> L. Their structures were elucidated by using spectroscopic methods, X-ray crystallographic analysis and comparison with those reported in the literature. Moreover, all isolated compounds <b>1-8</b> were evaluated for their antimicrobial activity against ESBL-producing <i>Escherichia coli</i> strain and methicillin-resistant <i>Staphylococcus aureus</i>.