The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models <i>In Vivo</i> Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ - Concepedia

Concepedia

Publication | Open Access

The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models <i>In Vivo</i> Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ

DOI Full Paper Access

25

Citations

42

References

2019

Year

Yu-an Yang, Howard H. Yang, Binwu Tang, Alex Man Lai Wu, Kathleen C. Flanders, Nellie Moshkovich, Douglas S. Weinberg, Michael A. Welsh, Jia Weng, Humberto de Jesús Ochoa Domínguez,

Clinical Cancer Research

Abstract

Contrary to dogma, tumor-suppressive responses to TGFβ are retained in some advanced metastatic tumors. Safe deployment of TGFβ antagonists in the clinic will require good predictive biomarkers.

References

	Year	Citations

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