A Facile and Convenient Synthetic Method for Fluorine-Containing Dibenzo[b,h][1,6]naphthyridines, Thiochromeno[3,2-c]quinolines, and Chromeno[3,2-c]quinolines

Abstract

Novel fluorine-containing dibenzo[b,h][1,6]naphthyridines (3), thiochromeno[3,2-c]quinolines (5), and chromeno[3,2-c]quinolines (7) were synthesized in moderate to high yields by the trifluoromethanesulfonic acid catalyzed cyclization of N-aryl-3-trifluoroacetyl-4-quinolylamines (2) and aryl 3-trifluoroacetyl-4-quinolyl sulfides (4) and ethers (6), easily prepared by