Concepedia

Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations

Sarkawt Hamad, Daniel Derichsweiler, Symeon Papadopoulos, Filomain Nguemo, Tomo Šarić, Agapios Sachinidis, Konrad Brockmeier, Jürgen Hescheler, Bastiaan J. Boukens, Kurt Pfannkuche

Theranostics · 2019 · 84 citations · 36 references

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Concepts

Abstract

: Combined inhibition of porcupine and tankyrase sub-pathways of Wnt signaling and continuous ascorbate supplementation, enable robust and efficient production of hiPSC-CMs.

References

36

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki et al. · Cell · 2007 · 20.2K citations

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DAVID: Database for Annotation, Visualization, and Integrated Discovery

Glynn Dennis, Brad T. Sherman, Douglas A Hosack et al. · Genome biology · 2003 · 9.5K citations · Full text

, , +16

Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts

Michael A. Laflamme, Kent Y Chen, Anna Naumova et al. · Nature Biotechnology · 2007 · 2.2K citations

, , +16

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

, , +10

Identifying biological themes within lists of genes with EASE

Douglas A Hosack, Glynn Dennis, Brad T. Sherman et al. · Genome biology · 2003 · 2K citations · Full text

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