Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity - Concepedia

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Functional Analysis of LDLR (Low-Density Lipoprotein Receptor) Variants in Patient Lymphocytes to Assess the Effect of Evinacumab in Homozygous Familial Hypercholesterolemia Patients With a Spectrum of LDLR Activity

DOI Full Paper Access

90

Citations

35

References

2019

Year

Poulabi Banerjee, Kuo‐Chen Chan, Michel Tarabocchia, Asier Benito‐Vicente, Ana Catarina Alves, Kepa B. Uribe, Mafalda Bourbon, Paul J. Skiba, Robert Pordy, Daniel A. Gipe,

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

These results suggest that evinacumab is effective for lowering LDL-C in patients with homozygous familial hypercholesterolemia, and the inhibition of ANGPTL3 in humans lowers LDL-C in a mechanism independent of the LDLR.

References

	Year	Citations

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