Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides

Abstract

The synthesis of 1,3,4-trisubstituted pyrroles via visible-light mediated photoredox catalyzed condensation of arylazides and aldehydes has been reported herein. The methodology avoids the use of stoichiometric oxidants and provides the corresponding <i>N</i>-containing arenes in good yields (up to 78%) and mild conditions. Mechanistic rationale is provided via a dedicated and combined spectroscopic/experimental investigations.