ARKIVOC · 2019 · 11 citations · 10 references
PharmacyChemistryMedicinal ChemistryDrug DesignOrganic ChemistryStructure-activity RelationshipsAntibacterial AgentsAntibacterial PharmacologyCrystal ChemistryStructure-activity Relationship AnalysisAntibacterial Drug DevelopmentAntibiotic DiscoveryBactericidal AgentsBacteriostatic AgentsNovel Antibacterial AgentsNovel Antibacterial Drug Discovery
The synthesis of dichlorodiazadienes containing nitro and methyl groups was performed starting from phenylhydrazones. The role of functional groups in the crystal design was investigated by X-ray crystallographic analysis. Pnicogen (N...Cl), halogen (Cl...O) and halogen-halogen(Cl...Cl) bonds were found in the synthesized compounds. Antibacterial studies were performed against five bacterial strains and potent antibacterial activity was detected against A.baumanii BDU32 and S.aureus BDU23.
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