<i>γ</i>‐Functionalization of <i>α,β</i>‐Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4‐Aryl‐2‐Bromopyridines

Abstract

Abstract This report describes the synthesis of 4‐aryl‐2‐halopyridines via γ ‐functionalization of α,β ‐unsaturated nitriles, which were obtained by the HWE reaction with the corresponding ketones. The key features of our methods involve a conjugated γ‐ enamine formation of α,β ‐unsaturated nitrile (enamino nitrile), followed by consecutive intramolecular cyclization, resulting in heteroaromatic compounds like 2‐halopyridines, α ‐pyrone, etc. magnified image