Concepedia

Publication | Open Access

MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress

DOIFull Paper Access

145

Citations

67

References

2019

Year

Jonathan P. Lambert, Timothy S. Luongo, Dhanendra Tomar, Pooja Jadiya, Erhe Gao, Xueqian Zhang, Anna Maria Lucchese, Devin W. Kolmetzky, N S Shah, John W. Elrod
Circulation

Abstract

We detail a new regulatory mechanism to modulate mtCU function and <sub>m</sub>Ca<sup>2+</sup> uptake. Our results suggest that MCUB-dependent changes in mtCU stoichiometry are a prominent regulatory mechanism to modulate <sub>m</sub>Ca<sup>2+</sup> uptake and cellular physiology.

References

YearCitations

Page 1