Autosomal recessive congenital ichthyosis due to homozygous variants in <i>NIPAL4</i> with a dramatic response to ustekinumab

Abstract

Autosomal recessive congenital ichthyosis is a genetically and phenotypically heterogenous group of scaling skin disorders. We describe a patient with ARCI caused by homozygous variants in NIPAL4, in whom the dermatologic phenotype and an associated arthropathy, markedly improved with ustekinumab.