Gene Editing: Friend or Foe? Evidence Indicates Endogenous Exosomes Can Deliver Functional gRNA and Cas9 Protein (Small 38/2019)

Abstract

In article number 1902686, Jie Wang, Fengmin Lu, and co-workers indicate the potential of exosomes as a safe and effective delivery vehicle of functional gRNA and Cas9 protein, and the exosomes-mediated delivery of gene editing activity to adjacent and distant cells or tissues, which may further complicate the off-target and safety concerns of the CRISPR/Cas9 system.