Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines

Abstract

The redox-neutral cascade dearomatization of indoles with <i>o</i>-aminobenzaldehydes has been realized via the hydride transfer strategy, achieving the condition- and substrate-controlled divergent synthesis of tetrahydroquinoline-fused spiroindolenines. The integration of hydride transfer-involved C(sp³)-H functionalization with dearomatization provides a promising platform for the construction of structurally diverse molecules.